Publication output


1.    Minde DP, Radli M, Forneris F, Maurice MM, Rüdiger SGD. Large extent of disorder in Adenomatous Polyposis Coli offers a strategy to guard Wnt signalling against point mutations. PLoS ONE. 2013; 8: e77257. doi: 10.1371/journal.pone.0077257.

2.    Yang Y, Barendregt A, Kamerling JP, Heck AJ. Analyzing protein micro-heterogeneity in chicken ovalbumin by high-resolution native mass spectrometry exposes qualitatively and semi-quantitatively 59 proteoforms. Anal Chem. 2013 Dec 17;85(24):12037-45.



3.    Karagöz GE, Duarte AM, Akoury E, Ippel H, Biernat J, Morán Luengo T, Radli M, Didenko T, Nordhues BA, Veprintsev DB, Dickey CA, Mandelkow E, Zweckstetter M, Boelens R, Madl T, Rüdiger SGD. Hsp90-Tau complex reveals molecular basis for specificity in chaperone action. Cell. 2014;156:963-74.

4.    Rosati S, Yang Y, Barendregt A, Heck AJR. Detailed mass analysis of structural heterogeneity in monoclonal antibodies using native mass spectrometry. Nature Protoc. 2014 Apr;9(4):967-76.

5.    Lössl, P., Snijder, J., Heck, A.J.R.. Boundaries of mass resolution in native mass spectrometry. J. Am. Soc. Mass Spectrom., 25, 906–917 (2014)

6.    van de Waterbeemd, M.J.*, Lössl, P.*, Gautier, V., Marino, F., Yamashita, M., Conti, E., Scholten, A., Heck, A.J.: Simultaneous assessment of kinetic, site-specific, and structural aspects of enzymatic protein phosphorylation. Angew. Chem. Int. Ed. Engl., 53, 9660–9664 (2014)

7.    JM Dörr, MC Koorengevel, M Schäfer, AV Prokofyev, S Scheidelaar, EAW van der Cruijsen, TR Dafforn, M Baldus, and JA Killian. 2014. Detergent-free isolation, characterization, and functional reconstitution of a tetrameric K+ channel: the power of native nanodiscs. Proc. Natl. Acad. Sci. U. S. A. 111:18607–18612.



8.    Hagemans D, van Belzen IAEM, Morán Luengo T, Rüdiger SGD. A script to highlight hydrophobicity and charge on protein surfaces. Front Mol Biosci. (2015) 2:56.

9.    McNulty R, Lokareddy RK, Roy A, Yang Y, Lander GC, Heck AJ, Johnson JE, Cingolani G.  Architecture of the Complex Formed by Large and Small Terminase Subunits from Bacteriophage P22. J Mol Biol. 2015 Oct 9;427(20):3285-99.

10. Brunner, A.M., Lössl, P., Liu, F., Huguet, R., Mullen, C., Yamashita, M., Zabrouskov, V., Makarov, A., Altelaar, A.F., Heck, A.J.: Benchmarking multiple fragmentation methods on an Orbitrap fusion for top-down phospho-proteoform characterization. Anal. Chem., 87, 4152–4158 (2015)

11. Gautier, V.*, Boumeester, A.J.*, Lössl, P.*, Heck, A.J.: Lysine conjugation properties in human IgGs studied by integrating high-resolution native mass spectrometry and bottom-up proteomics. Proteomics, 15, 2756–2765 (2015)

12. Koymans, K.J., Feitsma, L.J., Brondijk, T., Harma C., Aerts, P.C., Lukkien, E., Lössl, P., van Kessel, K.P.M., de Haas, C.J.C., van Strijp, J.A.G., Huizinga, E.G.: Structural basis for inhibition of TLR2 by staphylococcal superantigen-like protein 3 (SSL3). Proc. Natl. Acad. Sci. U. S. A, 112, 11018–11023 (2015)



13. Yang Y, Liu F, Franc V, Halim LA, Schellekens H, Heck AJR. Hybrid mass spectrometry approaches in glycoprotein analysis and their usage in scoring biosimilarity. Nature Commun. 2016 Nov 8;7:13397. doi: 10.1038/ncomms13397.

14. Schuller, J.M., Beck, F., Lössl, P., Heck, A.J., Förster, F.: Nucleotide-dependent conformational changes of the AAA+ ATPase p97 revisited. FEBS Lett., 590, 595–604 (2016)

15. Lössl, P., Brunner, A.M., Liu, F., Leney, A.C., Yamashita, M., Scheltema, R.A., Heck, A.J.: Deciphering the interplay among multisite phosphorylation, interaction dynamics, and conformational transitions in a tripartite protein system. ACS Cent. Sci., 2, 445–455 (2016)

16.      Lössl, P., van de Waterbeemd, M., Heck, A.J.: The diverse and expanding role of mass spectrometry in structural and molecular biology. EMBO J., 35, 2634–2657 (2016)

17. JM Dörr, S Scheidelaar, MC Koorengevel, JJ Dominguez Pardo, M Schäfer, CA van Walree, and JA Killian. 2016. The styrene–maleic acid copolymer: a versatile tool in membrane research. Eur. Biophys. J. 45:3–21.

18. S Scheidelaar, MC Koorengevel, CA van Walree, JJ Dominguez Pardo, JM Dörr, and JA Killian. 2016. Effect of polymer composition and pH on the solubilization of lipid membranes by styrene–maleic acid copolymers. Biophys. J. 111:1974–1986.

19. Ellgaard L., McCaul N., Chatsisvili A., Braakman I. (2016) Co- and post-translation protein folding in the ER. Traffic. Jun; 17 (6): 615-638.

20. Inge Leonie Van't Veer, Nadia Leloup, Alexander Egan, Bert Janssen, Nathaniel Martin, Waldemar Vollmer and Eefjan Breukink, Site specific immobilization of the peptidoglycan synthase PBP1B on a surface plasmon resonance chip surface. ChemBioChem, 2016.

21. Camilla De Nardis, Philip Lössl, Maartje van den Biggelaar, Pramod K Madoori, Nadia Leloup, Koen Mertens, Albert J R Heck & Piet Gros, Recombinant Expression of the Full-length Ectodomain of LDL Receptor-related Protein 1 (LRP1) Unravels pH-dependent Conformational Changes and the Stoichiometry of Binding with Receptor-associated Protein (RAP). Journal of Biological Chemistry, 2016.



22. Franc V, Yang Y, Heck AJR. Proteoform profile mapping of the human serum Complement component C9 reveals unexpected new features of N-, O- and C-glycosylation. Anal Chem. 2017 Feb 21. doi: 10.1021/acs.analchem.6b04527.

23. De Nardis, C., Lössl, P., van den Biggelaar, M., Madoori, P.K., Leloup, N., Mertens, K., Heck, A.J., Gros, P.: Recombinant Expression of the Full-length Ectodomain of LDL Receptor-related Protein 1 (LRP1) Unravels pH-dependent Conformational Changes and the Stoichiometry of Binding with Receptor-associated Protein (RAP). J. Biol. Chem., 292, 912–924 (2017)

24. Snijder J.*, Schuller J.M.*, Wiegard A., Lössl P., Schmelling N., Axmann I.M., Plitzko J.M., Förster F., Heck A.J. (2017) Structures of the cyanobacterial circadian oscillator frozen in a fully assembled state. Science, in press (2017)

25. JJ Dominguez Pardo, JM Dörr, A Iyer, V Subramaniam, and JA Killian. 2017. Solubilization of lipids and lipid phases by the styrene–maleic acid copolymer. Eur. Biophys. J. 46:91–101.

26. B Bersch, JM Dörr, A Hessel, JA Killian, and P Schanda. 2017. Proton-detected solid-state NMR spectroscopy of a zinc diffusion facilitator protein in native nanodiscs. Angew. Chem. Int. Ed. Engl. 56: 2508–2512.

27. Radli, M, Veprintsev DB, Rüdiger SGD. Production and purification of human Hsp90β in Escherichia coli. bioRxiv, 121996.